The genome of Onchocerca volvulus, agent of river blindness.
Identifieur interne : 000170 ( Main/Exploration ); précédent : 000169; suivant : 000171The genome of Onchocerca volvulus, agent of river blindness.
Auteurs : James A. Cotton [Royaume-Uni] ; Sasisekhar Bennuru [États-Unis] ; Alexandra Grote [États-Unis] ; Bhavana Harsha [Royaume-Uni] ; Alan Tracey [Royaume-Uni] ; Robin Beech [Canada] ; Stephen R. Doyle [Royaume-Uni] ; Matthew Dunn [Royaume-Uni] ; Julie C Dunning Hotopp [États-Unis] ; Nancy Holroyd [Royaume-Uni] ; Taisei Kikuchi [Royaume-Uni] ; Olivia Lambert [Royaume-Uni] ; Amruta Mhashilkar [États-Unis] ; Prudence Mutowo [Royaume-Uni] ; Nirvana Nursimulu [Canada] ; Jose M C. Ribeiro [États-Unis] ; Matthew B. Rogers [États-Unis] ; Eleanor Stanley [Royaume-Uni] ; Lakshmipuram S. Swapna [Canada] ; Isheng J. Tsai [Royaume-Uni] ; Thomas R. Unnasch [États-Unis] ; Denis Voronin [États-Unis] ; John Parkinson [Canada] ; Thomas B. Nutman [États-Unis] ; Elodie Ghedin [États-Unis] ; Matthew Berriman [Royaume-Uni] ; Sara Lustigman [États-Unis]Source :
- Nature microbiology [ 2058-5276 ] ; 2016.
Abstract
Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge of parasite biology. Here, we describe the chromosomes of O. volvulus and its Wolbachia endosymbiont. We provide the highest-quality sequence assembly for any parasitic nematode to date, giving a glimpse into the evolution of filarial parasite chromosomes and proteomes. This resource was used to investigate gene families with key functions that could be potentially exploited as targets for future drugs. Using metabolic reconstruction of the nematode and its endosymbiont, we identified enzymes that are likely to be essential for O. volvulus viability. In addition, we have generated a list of proteins that could be targeted by Federal-Drug-Agency-approved but repurposed drugs, providing starting points for anti-onchocerciasis drug development.
DOI: 10.1038/nmicrobiol.2016.216
PubMed: 27869790
Affiliations:
- Canada, Royaume-Uni, États-Unis
- Floride, Ontario, Québec
- Montréal, Tampa, Toronto
- Université McGill, Université de Floride du Sud, Université de Toronto
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000121
- to stream PubMed, to step Curation: 000121
- to stream PubMed, to step Checkpoint: 000121
- to stream Ncbi, to step Merge: 002150
- to stream Ncbi, to step Curation: 002150
- to stream Ncbi, to step Checkpoint: 002150
- to stream Main, to step Merge: 000170
- to stream Main, to step Curation: 000170
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The genome of Onchocerca volvulus, agent of river blindness.</title><author><name sortKey="Cotton, James A" sort="Cotton, James A" uniqKey="Cotton J" first="James A" last="Cotton">James A. Cotton</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Bennuru, Sasisekhar" sort="Bennuru, Sasisekhar" uniqKey="Bennuru S" first="Sasisekhar" last="Bennuru">Sasisekhar Bennuru</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Grote, Alexandra" sort="Grote, Alexandra" uniqKey="Grote A" first="Alexandra" last="Grote">Alexandra Grote</name><affiliation wicri:level="1"><nlm:affiliation>Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003</wicri:regionArea><wicri:noRegion>New York 10003</wicri:noRegion></affiliation></author><author><name sortKey="Harsha, Bhavana" sort="Harsha, Bhavana" uniqKey="Harsha B" first="Bhavana" last="Harsha">Bhavana Harsha</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Tracey, Alan" sort="Tracey, Alan" uniqKey="Tracey A" first="Alan" last="Tracey">Alan Tracey</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Beech, Robin" sort="Beech, Robin" uniqKey="Beech R" first="Robin" last="Beech">Robin Beech</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Parasitology, McGill University, Montreal, Quebec H9X 3V9, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Parasitology, McGill University, Montreal, Quebec H9X 3V9</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Doyle, Stephen R" sort="Doyle, Stephen R" uniqKey="Doyle S" first="Stephen R" last="Doyle">Stephen R. Doyle</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Dunn, Matthew" sort="Dunn, Matthew" uniqKey="Dunn M" first="Matthew" last="Dunn">Matthew Dunn</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Hotopp, Julie C Dunning" sort="Hotopp, Julie C Dunning" uniqKey="Hotopp J" first="Julie C Dunning" last="Hotopp">Julie C Dunning Hotopp</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation></author><author><name sortKey="Holroyd, Nancy" sort="Holroyd, Nancy" uniqKey="Holroyd N" first="Nancy" last="Holroyd">Nancy Holroyd</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Kikuchi, Taisei" sort="Kikuchi, Taisei" uniqKey="Kikuchi T" first="Taisei" last="Kikuchi">Taisei Kikuchi</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Olivia" sort="Lambert, Olivia" uniqKey="Lambert O" first="Olivia" last="Lambert">Olivia Lambert</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Mhashilkar, Amruta" sort="Mhashilkar, Amruta" uniqKey="Mhashilkar A" first="Amruta" last="Mhashilkar">Amruta Mhashilkar</name><affiliation wicri:level="4"><nlm:affiliation>Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida 33612</wicri:regionArea><orgName type="university">Université de Floride du Sud</orgName><placeName><settlement type="city">Tampa</settlement><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mutowo, Prudence" sort="Mutowo, Prudence" uniqKey="Mutowo P" first="Prudence" last="Mutowo">Prudence Mutowo</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Nursimulu, Nirvana" sort="Nursimulu, Nirvana" uniqKey="Nursimulu N" first="Nirvana" last="Nursimulu">Nirvana Nursimulu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Computer Science, University of Toronto, Toronto M5S 3G4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto M5S 3G4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ribeiro, Jose M C" sort="Ribeiro, Jose M C" uniqKey="Ribeiro J" first="Jose M C" last="Ribeiro">Jose M C. Ribeiro</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Rogers, Matthew B" sort="Rogers, Matthew B" uniqKey="Rogers M" first="Matthew B" last="Rogers">Matthew B. Rogers</name><affiliation wicri:level="1"><nlm:affiliation>Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224</wicri:regionArea><wicri:noRegion>Pennsylvania 15224</wicri:noRegion></affiliation></author><author><name sortKey="Stanley, Eleanor" sort="Stanley, Eleanor" uniqKey="Stanley E" first="Eleanor" last="Stanley">Eleanor Stanley</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Swapna, Lakshmipuram S" sort="Swapna, Lakshmipuram S" uniqKey="Swapna L" first="Lakshmipuram S" last="Swapna">Lakshmipuram S. Swapna</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8</wicri:regionArea><wicri:noRegion>Ontario M5G 1X8</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Isheng J" sort="Tsai, Isheng J" uniqKey="Tsai I" first="Isheng J" last="Tsai">Isheng J. Tsai</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Unnasch, Thomas R" sort="Unnasch, Thomas R" uniqKey="Unnasch T" first="Thomas R" last="Unnasch">Thomas R. Unnasch</name><affiliation wicri:level="4"><nlm:affiliation>Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida 33612</wicri:regionArea><orgName type="university">Université de Floride du Sud</orgName><placeName><settlement type="city">Tampa</settlement><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Voronin, Denis" sort="Voronin, Denis" uniqKey="Voronin D" first="Denis" last="Voronin">Denis Voronin</name><affiliation wicri:level="1"><nlm:affiliation>New York Blood Center, New York, New York 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York Blood Center, New York, New York 10065</wicri:regionArea><wicri:noRegion>New York 10065</wicri:noRegion></affiliation></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Computer Science, University of Toronto, Toronto M5S 3G4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto M5S 3G4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B" last="Nutman">Thomas B. Nutman</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Ghedin, Elodie" sort="Ghedin, Elodie" uniqKey="Ghedin E" first="Elodie" last="Ghedin">Elodie Ghedin</name><affiliation wicri:level="1"><nlm:affiliation>Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003</wicri:regionArea><wicri:noRegion>New York 10003</wicri:noRegion></affiliation></author><author><name sortKey="Berriman, Matthew" sort="Berriman, Matthew" uniqKey="Berriman M" first="Matthew" last="Berriman">Matthew Berriman</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Lustigman, Sara" sort="Lustigman, Sara" uniqKey="Lustigman S" first="Sara" last="Lustigman">Sara Lustigman</name><affiliation wicri:level="1"><nlm:affiliation>New York Blood Center, New York, New York 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York Blood Center, New York, New York 10065</wicri:regionArea><wicri:noRegion>New York 10065</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27869790</idno><idno type="pmid">27869790</idno><idno type="doi">10.1038/nmicrobiol.2016.216</idno><idno type="wicri:Area/PubMed/Corpus">000121</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000121</idno><idno type="wicri:Area/PubMed/Curation">000121</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000121</idno><idno type="wicri:Area/PubMed/Checkpoint">000121</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000121</idno><idno type="wicri:Area/Ncbi/Merge">002150</idno><idno type="wicri:Area/Ncbi/Curation">002150</idno><idno type="wicri:Area/Ncbi/Checkpoint">002150</idno><idno type="wicri:Area/Main/Merge">000170</idno><idno type="wicri:Area/Main/Curation">000170</idno><idno type="wicri:Area/Main/Exploration">000170</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The genome of Onchocerca volvulus, agent of river blindness.</title><author><name sortKey="Cotton, James A" sort="Cotton, James A" uniqKey="Cotton J" first="James A" last="Cotton">James A. Cotton</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Bennuru, Sasisekhar" sort="Bennuru, Sasisekhar" uniqKey="Bennuru S" first="Sasisekhar" last="Bennuru">Sasisekhar Bennuru</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Grote, Alexandra" sort="Grote, Alexandra" uniqKey="Grote A" first="Alexandra" last="Grote">Alexandra Grote</name><affiliation wicri:level="1"><nlm:affiliation>Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003</wicri:regionArea><wicri:noRegion>New York 10003</wicri:noRegion></affiliation></author><author><name sortKey="Harsha, Bhavana" sort="Harsha, Bhavana" uniqKey="Harsha B" first="Bhavana" last="Harsha">Bhavana Harsha</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Tracey, Alan" sort="Tracey, Alan" uniqKey="Tracey A" first="Alan" last="Tracey">Alan Tracey</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Beech, Robin" sort="Beech, Robin" uniqKey="Beech R" first="Robin" last="Beech">Robin Beech</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Parasitology, McGill University, Montreal, Quebec H9X 3V9, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Parasitology, McGill University, Montreal, Quebec H9X 3V9</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Doyle, Stephen R" sort="Doyle, Stephen R" uniqKey="Doyle S" first="Stephen R" last="Doyle">Stephen R. Doyle</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Dunn, Matthew" sort="Dunn, Matthew" uniqKey="Dunn M" first="Matthew" last="Dunn">Matthew Dunn</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Hotopp, Julie C Dunning" sort="Hotopp, Julie C Dunning" uniqKey="Hotopp J" first="Julie C Dunning" last="Hotopp">Julie C Dunning Hotopp</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201</wicri:regionArea><wicri:noRegion>Maryland 21201</wicri:noRegion></affiliation></author><author><name sortKey="Holroyd, Nancy" sort="Holroyd, Nancy" uniqKey="Holroyd N" first="Nancy" last="Holroyd">Nancy Holroyd</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Kikuchi, Taisei" sort="Kikuchi, Taisei" uniqKey="Kikuchi T" first="Taisei" last="Kikuchi">Taisei Kikuchi</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Olivia" sort="Lambert, Olivia" uniqKey="Lambert O" first="Olivia" last="Lambert">Olivia Lambert</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Mhashilkar, Amruta" sort="Mhashilkar, Amruta" uniqKey="Mhashilkar A" first="Amruta" last="Mhashilkar">Amruta Mhashilkar</name><affiliation wicri:level="4"><nlm:affiliation>Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida 33612</wicri:regionArea><orgName type="university">Université de Floride du Sud</orgName><placeName><settlement type="city">Tampa</settlement><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mutowo, Prudence" sort="Mutowo, Prudence" uniqKey="Mutowo P" first="Prudence" last="Mutowo">Prudence Mutowo</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Nursimulu, Nirvana" sort="Nursimulu, Nirvana" uniqKey="Nursimulu N" first="Nirvana" last="Nursimulu">Nirvana Nursimulu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Computer Science, University of Toronto, Toronto M5S 3G4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto M5S 3G4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ribeiro, Jose M C" sort="Ribeiro, Jose M C" uniqKey="Ribeiro J" first="Jose M C" last="Ribeiro">Jose M C. Ribeiro</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Rogers, Matthew B" sort="Rogers, Matthew B" uniqKey="Rogers M" first="Matthew B" last="Rogers">Matthew B. Rogers</name><affiliation wicri:level="1"><nlm:affiliation>Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224</wicri:regionArea><wicri:noRegion>Pennsylvania 15224</wicri:noRegion></affiliation></author><author><name sortKey="Stanley, Eleanor" sort="Stanley, Eleanor" uniqKey="Stanley E" first="Eleanor" last="Stanley">Eleanor Stanley</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Swapna, Lakshmipuram S" sort="Swapna, Lakshmipuram S" uniqKey="Swapna L" first="Lakshmipuram S" last="Swapna">Lakshmipuram S. Swapna</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8</wicri:regionArea><wicri:noRegion>Ontario M5G 1X8</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Isheng J" sort="Tsai, Isheng J" uniqKey="Tsai I" first="Isheng J" last="Tsai">Isheng J. Tsai</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Unnasch, Thomas R" sort="Unnasch, Thomas R" uniqKey="Unnasch T" first="Thomas R" last="Unnasch">Thomas R. Unnasch</name><affiliation wicri:level="4"><nlm:affiliation>Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida 33612, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida 33612</wicri:regionArea><orgName type="university">Université de Floride du Sud</orgName><placeName><settlement type="city">Tampa</settlement><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Voronin, Denis" sort="Voronin, Denis" uniqKey="Voronin D" first="Denis" last="Voronin">Denis Voronin</name><affiliation wicri:level="1"><nlm:affiliation>New York Blood Center, New York, New York 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York Blood Center, New York, New York 10065</wicri:regionArea><wicri:noRegion>New York 10065</wicri:noRegion></affiliation></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Computer Science, University of Toronto, Toronto M5S 3G4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto M5S 3G4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B" last="Nutman">Thomas B. Nutman</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892</wicri:regionArea><wicri:noRegion>Maryland 20892</wicri:noRegion></affiliation></author><author><name sortKey="Ghedin, Elodie" sort="Ghedin, Elodie" uniqKey="Ghedin E" first="Elodie" last="Ghedin">Elodie Ghedin</name><affiliation wicri:level="1"><nlm:affiliation>Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Genomics and Systems Biology, Department of Biology, New York University, New York, New York 10003</wicri:regionArea><wicri:noRegion>New York 10003</wicri:noRegion></affiliation></author><author><name sortKey="Berriman, Matthew" sort="Berriman, Matthew" uniqKey="Berriman M" first="Matthew" last="Berriman">Matthew Berriman</name><affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea><wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion></affiliation></author><author><name sortKey="Lustigman, Sara" sort="Lustigman, Sara" uniqKey="Lustigman S" first="Sara" last="Lustigman">Sara Lustigman</name><affiliation wicri:level="1"><nlm:affiliation>New York Blood Center, New York, New York 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York Blood Center, New York, New York 10065</wicri:regionArea><wicri:noRegion>New York 10065</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature microbiology</title><idno type="eISSN">2058-5276</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge of parasite biology. Here, we describe the chromosomes of O. volvulus and its Wolbachia endosymbiont. We provide the highest-quality sequence assembly for any parasitic nematode to date, giving a glimpse into the evolution of filarial parasite chromosomes and proteomes. This resource was used to investigate gene families with key functions that could be potentially exploited as targets for future drugs. Using metabolic reconstruction of the nematode and its endosymbiont, we identified enzymes that are likely to be essential for O. volvulus viability. In addition, we have generated a list of proteins that could be targeted by Federal-Drug-Agency-approved but repurposed drugs, providing starting points for anti-onchocerciasis drug development.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Floride</li><li>Ontario</li><li>Québec</li></region><settlement><li>Montréal</li><li>Tampa</li><li>Toronto</li></settlement><orgName><li>Université McGill</li><li>Université de Floride du Sud</li><li>Université de Toronto</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Cotton, James A" sort="Cotton, James A" uniqKey="Cotton J" first="James A" last="Cotton">James A. Cotton</name></noRegion><name sortKey="Berriman, Matthew" sort="Berriman, Matthew" uniqKey="Berriman M" first="Matthew" last="Berriman">Matthew Berriman</name><name sortKey="Doyle, Stephen R" sort="Doyle, Stephen R" uniqKey="Doyle S" first="Stephen R" last="Doyle">Stephen R. Doyle</name><name sortKey="Dunn, Matthew" sort="Dunn, Matthew" uniqKey="Dunn M" first="Matthew" last="Dunn">Matthew Dunn</name><name sortKey="Harsha, Bhavana" sort="Harsha, Bhavana" uniqKey="Harsha B" first="Bhavana" last="Harsha">Bhavana Harsha</name><name sortKey="Holroyd, Nancy" sort="Holroyd, Nancy" uniqKey="Holroyd N" first="Nancy" last="Holroyd">Nancy Holroyd</name><name sortKey="Kikuchi, Taisei" sort="Kikuchi, Taisei" uniqKey="Kikuchi T" first="Taisei" last="Kikuchi">Taisei Kikuchi</name><name sortKey="Lambert, Olivia" sort="Lambert, Olivia" uniqKey="Lambert O" first="Olivia" last="Lambert">Olivia Lambert</name><name sortKey="Mutowo, Prudence" sort="Mutowo, Prudence" uniqKey="Mutowo P" first="Prudence" last="Mutowo">Prudence Mutowo</name><name sortKey="Stanley, Eleanor" sort="Stanley, Eleanor" uniqKey="Stanley E" first="Eleanor" last="Stanley">Eleanor Stanley</name><name sortKey="Tracey, Alan" sort="Tracey, Alan" uniqKey="Tracey A" first="Alan" last="Tracey">Alan Tracey</name><name sortKey="Tsai, Isheng J" sort="Tsai, Isheng J" uniqKey="Tsai I" first="Isheng J" last="Tsai">Isheng J. Tsai</name></country><country name="États-Unis"><noRegion><name sortKey="Bennuru, Sasisekhar" sort="Bennuru, Sasisekhar" uniqKey="Bennuru S" first="Sasisekhar" last="Bennuru">Sasisekhar Bennuru</name></noRegion><name sortKey="Ghedin, Elodie" sort="Ghedin, Elodie" uniqKey="Ghedin E" first="Elodie" last="Ghedin">Elodie Ghedin</name><name sortKey="Grote, Alexandra" sort="Grote, Alexandra" uniqKey="Grote A" first="Alexandra" last="Grote">Alexandra Grote</name><name sortKey="Hotopp, Julie C Dunning" sort="Hotopp, Julie C Dunning" uniqKey="Hotopp J" first="Julie C Dunning" last="Hotopp">Julie C Dunning Hotopp</name><name sortKey="Lustigman, Sara" sort="Lustigman, Sara" uniqKey="Lustigman S" first="Sara" last="Lustigman">Sara Lustigman</name><name sortKey="Mhashilkar, Amruta" sort="Mhashilkar, Amruta" uniqKey="Mhashilkar A" first="Amruta" last="Mhashilkar">Amruta Mhashilkar</name><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B" last="Nutman">Thomas B. Nutman</name><name sortKey="Ribeiro, Jose M C" sort="Ribeiro, Jose M C" uniqKey="Ribeiro J" first="Jose M C" last="Ribeiro">Jose M C. Ribeiro</name><name sortKey="Rogers, Matthew B" sort="Rogers, Matthew B" uniqKey="Rogers M" first="Matthew B" last="Rogers">Matthew B. Rogers</name><name sortKey="Unnasch, Thomas R" sort="Unnasch, Thomas R" uniqKey="Unnasch T" first="Thomas R" last="Unnasch">Thomas R. Unnasch</name><name sortKey="Voronin, Denis" sort="Voronin, Denis" uniqKey="Voronin D" first="Denis" last="Voronin">Denis Voronin</name></country><country name="Canada"><region name="Québec"><name sortKey="Beech, Robin" sort="Beech, Robin" uniqKey="Beech R" first="Robin" last="Beech">Robin Beech</name></region><name sortKey="Nursimulu, Nirvana" sort="Nursimulu, Nirvana" uniqKey="Nursimulu N" first="Nirvana" last="Nursimulu">Nirvana Nursimulu</name><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><name sortKey="Swapna, Lakshmipuram S" sort="Swapna, Lakshmipuram S" uniqKey="Swapna L" first="Lakshmipuram S" last="Swapna">Lakshmipuram S. Swapna</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000170 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000170 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27869790
|texte= The genome of Onchocerca volvulus, agent of river blindness.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27869790" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |